Since the follicular walls in the pilo-sebaceous unit is intact before adolescence, it has been theorized that if colonization of Proprionibacterium acnes occurs in sufficient quantities they create antigenic molecules that stimulate the initiation of inflammation. Proprionibacterium acnes is able to produce proteinases, lipase, and hyaluronate lyase all of which can serve as the accelerators or promoters of the inflammatory infiltrate which is composed of neutrophils and lymphocytes.

Hormonal Cause of Acne

The key player in the cause of acne in adolescence is hormones. At this phase androgens interact with receptors on the sebaceous glands and promote activation of the sebaceous gland to hypertrophy and so induce more sebaceous production of lipids and free fatty acids which dilate the follicular canal. More specifically, there is evidence for enhanced peripheral metabolic transformation of the androgen testosterone to dihydrotestosterone at the level of the skin in persons suffering from acne.

How Acne Forms

The basic lesion in this condition called acne vulgaris is the comedo. When exposed to oxygen the comedo turns dark and forms what you know as a blackhead. The comedo is made by retention of layers of devitalized skin called keratin in the walls of the follicles. In addition to hyperkeratosis (which is thickening or trapped layers of keratin), there is an accumulation of sebum. The combination of the keratin and the sebum leads to a plugging of the opening of the follicular canal, and papules are made by inflammation around the comedones. Depending on the degree of inflammation, pustules, granulomatous reactions, cars, nodules, cysts, and keloids can develop.

Development of Acne

Inflammatory Reaction

Airborne contamination and other harmful materials further aggravate the inflammatory reaction. As microbes begin to grow inside the clogged pore your defensive system reacts by releasing granulocytes and macrophages, which are types of white blood cells that eliminate the microbes. The inflammation process is necessary to eliminate the continuing effects of excess bacteria and signal the body to repair the harm to tissues. Often times the defensive response system can't stop the reproduction of acne bacteria due to lack of white blood cells or an impaired system.

Activity of the Sebaceous Gland

When a comedo is blocking the outlet of the sebum ducts, the sebaceous glands continue to form sebum, which gathers in the sebum canal augmenting the comedo in size. The expansion in size results in pressure and leads to a further intense inflammation reaction in the nearby skin and produces discomfort, redness, swelling, and a mass (pimple, redhead, acne papule).

Growth of Acne Bacteria

The above factors encourage the growth of microbes and result in infection inside the duct, the sebaceous gland, and nearby tissue. The commencement of the infection produces further inflammatory alterations, therefore beginning a cycle of accentuated blockage of the outflow of sebum which produces even more pressure, inflammation, and progressing infection causing cysts and pustules to occur. The consequence on skin tissues caused by such infections is very damaging and the healing process commonly results in a scar.

Treatments For Acne

In order to find a good pimple remedy, you must keep in mind that all individuals have different needs. Try a variety of acne products, beginning with the milder one, until you find what works for you. A good skin treatment can be the end of your acne.

Scars, blemishes and marks produced by various acne conditions can now be quickly eliminated thanks to a biological skin care product made with a non-allergenic, non-irritant special ingredient for the regeneration of your skin.